In the hilarious parody video from the Animation Domination High-Def YouTube comedy channel, Cartoon Network’s beloved children’s superheroes The Powderpuff Girls are mashed together with HBO’s New York based, 20 something, female prominent drama Girls.

The results are an amusing clip that explores what Blossom, Bubbles and Buttercup would be like if they were instead made with sugar, spice, narcissism and chemical X. Character design for the visuals were done by artist Raye Rodriquez and seem interestingly timed, as Cartoon Network has announced that a new season of the show has been cemented for 2016.

More comedic animations from the ADHD YouTube channel can be viewed here.